High-dose metoclopramide + lorazepam versus low-dose metoclopramide + lorazepam + dehydrobenzperidol in the treatment of cisplatin-induced nausea and vomiting

Antiemetic prophylaxis with high dose metoclopramide or lorazepam in vomiting induced by chemotherapy.

1879 Antiemetic prophylaxis with high dose metoclopramide or lorazepam in vomiting induced by chemotherapy Emesis induced by cytotoxic agents is an important side effect that may determine a patient's acceptance of cancer chemotherapy and may be responsible for his defaulting from potentially effective treatment. Despite the availability of several antiemetic drugs, this complication is general...

Metoclopramide: An Antiemetic in Chemotherapy Induced Nausea and Vomiting

Chemotherapy induced nausea and vomiting (CINV) are two of the most feared adverse events experienced by cancer patients undergoing chemotherapy. Metoclopramide was derived from procainamide in the 1950s and one of the first drugs investigated in the prophylaxis of nausea and vomiting induced by chemotherapy. The breakthrough came in 1981 with the recognition that high-dose metoclopramide was e...

Anti-nausea effects and pharmacokinetics of ondansetron, maropitant and metoclopramide in a low-dose cisplatin model of nausea and vomiting in the dog: a blinded crossover study

BACKGROUND Nausea is a subjective sensation which is difficult to measure in non-verbal species. The aims of this study were to determine the efficacy of three classes of antiemetic drugs in a novel low dose cisplatin model of nausea and vomiting and measure change in potential nausea biomarkers arginine vasopressin (AVP) and cortisol. A four period cross-over blinded study was conducted in eig...

Domperidone or metoclopramide in preventing chemotherapeutically induced nausea and vomiting.

Long-lasting adverse effects after short-term low-dose treatment with metoclopramide for vomiting.

Metoclopramide is commonly used to treat vomiting caused by seasickness and acute gastroenteritis on cruise ships and serious adverse effects have not been reported from use at sea. We report severe long-lasting adverse effects in a young female seafarer following short-term, low-dose use of metoclopramide. During rough seas a 25-year-old female musician on a cruise vessel presented with nausea...